The 17th Meeting of the Society for Natural Immunity


Scientific Program

Monday, May 28, 2018

3:00 – 8:00 pm                  Registration Open                                                     

5:00 – 5:30 pm                  Welcome - Jordan Orange                                       

5:30 – 6:00 pm                  Keynote Lecture - Mark Davis

6:00 – 6:30 pm                  Alessandro Moretta Tribute
                                            Eric Vivier

6:30 – 9:00 pm                  Exhibition Hall open                                                  

7:00 – 9:30 pm                  Welcome Dinner                                                           


Tuesday, May 29, 2018

6:00 – 3:00 pm                  Registration Open                                                       

6:30 – 8:30 am                  Breakfast 

8:30 – 10:00 am                NK Cells and Viral Immunity 
                                            Chair:    Domenico Mavilio                             

8:30 – 8:50 am                  Marcus Altfeld

8:50 – 9:10 am                  Mark Tompkins

9:10 – 9:30 am                  Lewis Lanier

9:30 – 9:50 am                  Christine Biron

9:50 – 10:10 am                Mariapi Degli-Esposti

10:10 – 10:30 am             Coffee Break       

10:10 – 1:00 pm                Exhibition Hall open                    

10:30 – 12:00 pm             NK Cells and Bacterial Fungal and Parasitic Infection 
                                            Chair:    Eric Long   

10:30 – 10:50 am            Ofer Mandelboim

10:50 – 11:10 am             Ramakrishna Vankayalapati

11:10 – 11:20 am     1      KIR2DS2 recognizes highly conserved viral peptides in the context of MHC class I
                                           Salim Khakoo

11:20 – 11:30 am     2      Structure of the murine cytomegalovirus encoded m12 immunoevasin bound
                                           to the inhibitory NKR-P1B receptor
                                           Richard Berry

11:30 – 11:40 am     3      Granule-dependent NK cell killing of Cryptococcus requires kinesin to reposition
                                           the cytolytic machinery for directed cytotoxicity
                                           Henry Ogbomo

11:40 – 12:00 pm             Stipan Jonjic

12:00 – 1:30 pm                Lunch & Networking                                                  

1:30 – 3:00 pm                  NK Autoimmunity, Deficiency and Exhaustion*  
                                            Chair:    Konrad Krzewski

1:30 – 1:50 pm                  Jordan Orange

1:50 – 2:10 pm                  Yenan Bryceson

2:10 – 2:30 pm                  Mira Barda-Saad

2:30 – 2:50 pm                  Anthony French

2:50 – 3:00 pm     4           gp91phox is a metabolic checkpoint regulator in NK cells
                                            Simon Nicoletti

3:00 – 6:00 pm                  Free Time

6:00 – 8:00 pm                  Registration Open                                                      

6:00 – 7:00 pm                  Dinner                                                                          

6:00 – 9:00 pm                  Exhibition Hall open                                                  

7:00 – 9:00 pm                  Poster Session 1                   

           21       Characterization of the impact of daclizumab beta on circulating natural killer cells
                      by mass cytometry
                      Thanmayi Ranganath

           23       A novel ILC precursor restricted to ILC3 and NK development in humans  
                      Luxi Chen                                                              

    25       NK cell cytotoxicity of Pseudomonas aeruginosa requires flagellar motility and is
               MAP kinase dependent
               Khusraw Jamil

    27       Migration of ex vivo-expanded natural killer cells in human breast cancer
               xenograft models
              Tung Nguyen Thanh Uong

    29       HLA-DP molecules can serve as ligands for the natural cytotoxicity receptor NKp44
               Annika Niehrs

    31       Ex vivo generation and expansion of CAR-engineered NK cells for adoptive cancer
               Pranav Oberoi

    33       Clinical and Immunological Anti-Cancer Effects of Canine IL-15 Therapy Combined
               with Metronomic Cyclophosphamide in Dogs with Cancer
               Sang-Ki Kim

    35       IL-15 promotes polyfunctional NK cell responses to influenza by boosting IL-12
               Helen Wagstaffe

    37       CD96 correlates to human NK cell exhaustion and predicts the prognosis of
               HCC patients
               Cheng Sun

    39       Ex vivo generated Natural Killer cells efficiently mediate ovarian cancer
               killing in vitro and in vivo
               Jolien Van Der Meer

    41       ILC1 confer early host protection at initial sites of viral infection
               Timothy O'Sullivan

    43       The transcription factor PBX1 drives natural killer cell maturation by
                promoting intrinsic factors
               Yonggang Zhou

    45       Interferon-g Signaling Guides the Intrahepatic Development of Tissue-resident
               NK Cells
               Lu Bai

    47       Formation and Maintenance of Memory IL-7Ra+ ILC1s via a Lymph Node-Liver Axis
               Xianwei Wang

    49       Stimulation of liver-resident natural killer (NK) cells with adenovirus
               Padmapriya Sekar

    51       A unique NK cell population undergoes extramedullary maturation via T-bet
               Baohui Wang

    53       TGF-ß signaling suppresses tumor surveillance by inducing transdifferentiation of
               conventional NK cells into ILC1-like cells
               Fernando SF Guimaraes

    55       A novel Chronic Hepatitis B virus Infection mouse model
               Xiaolei Hao

    57       Modulation of KIR3DS1 ligand expression by HIV-1
               Angelique Hölzemer

    59       NK1.1 receptor ligation primes NK cells for IL2-mediated metabolic and functional responses  
               Nidhi Kedia-Mehta

    61       Differential NK cell recognition of artificial immune synapses shaped as
                dots or donuts
                 Quentin Verron

      63       ETS-1 is a critical regulator of development and function of human natural killer
                 cells and ILC3s    
                 Sigrid Wahlen

      65       Chronic stimulation of NK cells through NKG2C drives expression of checkpoint
                  inhibitors and functional exhaustion
                 Aimee Merino

      67       The exopolysaccharide Pel but not Psl of Pseudomonas aeruginosa is required in
                  natural killer cell-mediated anti-Pseudomonas activity
                 Mark Hasell

      69       In Vitro Re-education of Mature Human NK Cells
                 Jason Pugh

      71       Granzyme B is required for NK cell-mediated antifungal activity
                 Adley CH Mok

      73       Natural Killer cells and Cytotoxic T Lymphocytes are required for successful
                 combination immunotherapy in xenograft model of human lung adenocarcinoma
                 Duy Le

      75       HHV-6A proteins U20 and U21 mediate evasion of NK cell killing by
                 downregulating NKG2D ligands
                 Alexandra Duev-Cohen

      77       Cytotoxic TRAIL+ NK cells overcome HCV inhibition and master anti-viral
                 Ester Badami

      79       ‘Adaptive’ NK Cell Responses to Plasmodium falciparum-infected Erythrocytes
                  Samuel Sherratt

       81       Timelapse FRET imaging reveals the correlation between the strength of ERK
                  activation in NK cells and the fate of conjugated target cells
                   Hiroshi Ichise

      83       Characterization of Poliovirus Receptor in 3D cultures of Renal Carcinoma cells
                  and its role in shaping Natural Killer cell activity in the tumor microenvironment
                  Valentina Carannante

      85       Assessment of the heterogeneity of human NK cells through deep
                  immune-receptor profiling
                  Christian Körner

      87        Characterization of NK cells in primary sclerosing cholangitis
                  Annika Langeneckert

      89       Natural Killer Cell Maturation Phenotypes In Non-Infectious Systemic
                  Inflammation Versus Septic Shock
                  Bianca Himmelhan

      91       Epigenetic control of innate and adaptive immune memory
                  Colleen Lau

      93       PD-1 is expressed at low levels on all peripheral blood Natural Killer cells and is
                  a significant suppressor of NK function against PD-1 ligand expressing tumor targets
                  Zachary Davis

      95       NK cell phenotypic expression patterns are contrasting and tissue specific in
                  Influenza A infection
                  Lynn Bimler    

      97       Structural and regulatory diversity shape HLA-C protein expression levels
                  Gurman Kaur

      99       Type 2 cytokines modulate human natural killer cell responses
                  David Ohayon

     101     Identification and characterization of KLRC2 (NKG2C)+ memory and memory-like
                 NK cells in SIV infection by RNA-Flow Cytometry     
                 Daniel Ram  

     103     Structural Insights into the Lineage III Killer-Cell Immunoglobulin-like Receptors
                 Phillip Pymm

     105     Infectious complications and NK cell depletion following daratumumab treatment
                 of Multiple Myeloma 
                 Michael Chrobok   

     107     The transcription factor PLZF is associated with CXCR6 and CD69 co-expression
                 on hepatic and blood-derived human CD56bright NK cells 
                 Leonard Hess

     109     Characterization of rat innate lymphoid cells (ILCs)
                 Amanda Sudworth

     111     Long-term outcome of serial killing NK cells
                 Karolin Guldevall

     113     Characterization of a novel immunodeficiency due to lack of the
                 Fc receptor CD16A 
                 Adriana Patricia Pérez Portilla  

     115     Single cell imaging of KIR educated NK cells
                 Ludwig Brandt

      117     Autologous locoregional NK cell immunotherapy for patients with recurrent posterior
                  fossa malignant brain tumors
                  Prashant Trikha

      119     Mouse Natural Killer (NK) cells keep their educational profile after
                  cytokine-mediated activation
                  Tatiana Michel

      121     Expression of ligands of NKG2D/DNAM-1 receptors induced by Dengue virus
                  Davis Beltran

      123     Transcriptional Profiling of Human Bone marrow Resident Natural Killer Cells
                   Reveals a Unique Surface Molecule Repertoire Shared With Resident Memory
                   CD8+ T Cells  
                   Janine Melsen 

      125      Effects of toll like receptor stimulation on IL-21 expanded NK cells for the
                   treatment of neuroblastoma
                   Margaret Lamb

       127     Antigen-specific targeting of cancer by NK cells via next generation
                   TriKE molecules
                   Martin Felices

       129     Fully automated separation, cultivation, and genetic modification of NK cells
                   Nina Möker

       131     Role of cytokine milieu and short-term hypoxia responses on natural killer cell
                   effector functions and metabolic switching
                   Sonia Yamile Velasquez

       133     Identification and functional compartmentalisation of tissue NK cell subsets in
                   pregnancy and in ovarian cancer
                   Oisin Huhn

       135     CISH regulates human natural killer (NK) cell development and inhibits NK
                   cell exhaustion
                  Huang Zhu

      137     NK cells inhibit Plasmodium falciparum growth in red blood cells through
                  antibody-dependent cellular cytotoxicity
                  Gunjan Arora

      139     CD16-IL15-CLEC12A Trispecific Killer Engager (TriKE) drives NK cell
                  expansion, survival, and antigen specific killing of Cancer Stem Cells in MDS and AML
                  Upasana Arvindam

      141     Kinetics of the liver resident NK cell compartment
                  Garvin Dodard

      143     A Novel HCMV Protein Downregulates an NK cell Ligand to Avoid Attack
                  Liat Dassa

      145     PKM2 integrates Natural Killer cell metabolism and signaling
                 Jessica Walls

      147     NK cells can influence the progression of non-immunogenic cancers
                 Jai Rautela

     149     Impact of KIR allele polymorphism on the structuration and the function of
                 KIR2D NK cell repertoire
                 Bercelin Maniangou Zonzeka

     151     Impact of Polymorphisms in TRAIL among hepatectomy for primary
                 hepatocellular carcinoma
                 Yuki Imaoka

     153     MIP-1b secreting but poorly cytotoxic CD56negCD16pos NK cells accumulate in
                 Kenyan children with endemic Burkitt's lymphomas
                Catherine Forconi

     155     Natural Killer (NK) cells in chronic bacterial lung infection
                 Neha Patil

     157     Prediction of NK cell sensitivity towards tumour cells
                 Amanda Van Vliet

     159     Minimal degranulations in Natural killer (NK) cells can mediate killing of
                 single target cells
                 Lavesh Gwalani

     161     NK cells engage a granule exocytosis- and death receptors-independent
                 cytotoxicity pathway when facing pre-B leukemic target cells
                 Simon Nicoletti

     163     Natural killer cell memory to non-CMV antigens
                 Laura Angelo

     165     Inhibition of BCL2 family members reduces host NK cell activity to promotes
                 allogeneic donor T cell engraftment in a reduced intensity conditioning model
                  preserving the graft-versus-leukemia effect without promoting graft-versus-host disease
                 Yuhao Jiao

     167     A genome-wide CRISPR/Cas9-based screen identifies killer-cell immunoglobulin-like
                 receptors containing a D0 domain as heparan sulfate-binding proteins
                 Wilfredo Garcia-Beltran

     169     Defining the functional role of CD56 in human NK cell cytotoxicity
                 Justin Tyme Gunesch

     171     Understanding the functional differences between NK subsets expressing different
                 KIR2DL1 alleles within the same donor
                 Andrew Sharkey

     173     Conformational Properties of the Cytoplasmic Region of KIR3DL1 Upon
                Interaction with SHP-2
                Kerry Campbell

     175     ILC-killer: a distinct human ILC subset with KIR-independent cytotoxicity
                Bérengère Salomé

     177     Natural killer cells promote fetal development through the secretion of
                growth-promoting factors
                Binqing Fu

     179     A higher peritoneal NK cell frequency is correlated with better outcome in
                advanced ovarian carcinoma
                Ralph Maas

     181     Host resistance to endotoxic shock requires the neuroendocrine regulation of
                group 1 innate lymphoid cells
                Linda Quatrini

     183     Combination of monalizumab and durvalumab as a potent immunotherapy
                treatment for solid human cancers
                Pascale Andre

     185     NK cells in treated HIV-infected children display altered phenotype and function
                Sanjana Mahapatra

     187     Adrenergic signalling negatively regulates IFN-y production by NK cells during
                MCMV infection
                Elisabeth Wieduwild

      189     Role of natural killer cell receptors in regulation and killing of human pluripotent
                 stem cells
                 Camilla Henden

      191     NK cell deficiency identified in Cutis Laxa patients carrying genetic variants in
                 Levi Watkin

      193     Robust NK cells transduction technique opens new possibilities for cancer
                 Aurélien Colamartino

      195     Natural killer cells are tolerized by damage-associated molecular patterns
                 Jeanette Boudreau

      197     The activating human NK cell receptor KIR2DS2 recognizes a ß2-microglobulin
                 independent ligand on cancer cells
                 Erik Dissen

     199     KIR2DL1 and KIR2DS1 allelic variations and HLA-C2 level expression highly
                 impact NK cells phenotype and function
                 Jean-Benoit Le Luduec

      201     Natural Killer Cells - Engineered (CAR-NK): Next Generation Candidates for
                  Allogenic Immune Therapies - Creating Better Scalable Culture Systems
                  to meet Therapy Doses 
                  Erica Heipertz

      203     The Transcription Factor Aryl Hydrocarbon Receptor Modulates the Function
                  of Human CD56bright NK Cells
                  Uriel Moreno-Nieves

      205     The NK cell evaluation and research (NEAR) Program: A translational Research
                  Collaborative to accelerate Diagnosis and Discovery of NK Cell Deficiencies
                  Tram Cao

      207     Dengue Virus Down-regulates Ligands for the NK Cell Activating Receptor NKG2D
                 Peifang Sun

      209     Comparative analysis of IL-21 and autologous feeder cell-driven ex vivo expansion
                  after fully-automated clinical grade separation of primary NK cells
                  Olaf Oberschmidt

      211     Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1
                  with C2+ HLA-C in Two Indigenous Human Populations in Southern Africa
                  Paul Norman

      213     Enhanced Spontaneous Anti-Tumor Cytotoxicity of Natural Killer Cells in
                  Cutaneous T-Cell Lymphoma Patients
                  Bethany Mundy-Bosse

      215     Potent Ex Vivo Expanded, Human CD34+ Cord Blood-derived Natural Killer
                  Cells for Cancer Immunotherapy
                  Xiaokui Zhang


Wednesday, May 30, 2018

6:00 – 3:00 pm                  Registration Open

6:30 – 8:30 am                  Breakfast   

8:30 – 10:00 am                NK Cells and Anti-Tumor Immunity
                                            Chair:    Bjorn Onfelt

 8:30 – 8:50 am                  David Raulet

8:50 – 9:10 am                  Adelheid Cerwenka

9:10 – 9:30 am                  Nicholas Huntington

9:30 – 9:40 am       5         AML-derived AHR ligands directly upregulate microRNA-29b to impair
                                           NK cell development and function
                                           Bethany Mundy-Bosse

9:40 – 9:50 am       6         Natural Killer cells control tumor growth by sensing a growth factor
                                            Alexander Barrow

9:50 – 10:00 am     7         Antibody-mediated inhibition of MICA/B shedding restores NK cell immunity
                                            against tumors
                                            Lucas Ferrari de Andrade

10:00 – 10:30 am             Coffee Break

10:00 – 1:00 pm                Exhibition Hall open

10:30 – 12:00 pm             NK Cell Activation and Function
                                            Chair:    Petter Hoglund

10:30 – 10:50 am             Carsten Watzl

10:50 – 11:10 am             Daniel Davis

11:10 – 11:30 am             Angela Santoni

11:30 – 11:50 am             Clair Gardiner

11:50 – 12:00 pm    8       Direct evidence for long-lived homotypic clonal expansions of NK cells with
                                           adaptive characteristics in a rhesus macaque barcoded transplantation model
                                           Chuanfeng Wu

12:00 – 1:30 pm                Lunch & Networking

1:30 – 3:00 pm                  NK Cell Immunogenetics and Roles in Transplant*
                                            Chair:    Megan Cooper

1:30 – 1:50 pm                  Peter Parham

1:50 – 2:10 pm                  Katharine Hsu

2:10 – 2:30 pm                  Mary Carrington

2:30 – 2:50 pm                  Katy Rezvani

2:50 – 3:00 pm       9         Identification of an elaborate NK-specific system regulating HLA-C expression
                                             Stephen Anderson

3:00 – 3:30 pm                  The NIH NK cell portfolio and funding opportunities
                                            Cheryl Lapham

3:30 – 6:00 pm                  Free Time

6:00 – 8:00 pm                  Registration Open

6:00 – 7:00 pm                  Dinner 

6:00 – 9:00 pm                  Exhibition Hall open

7:00 – 9:00 pm                  Poster Session 2  

     22       Size matters: roles of LYST and actin meshwork in controlling Natural Killer cell
                exocytosis in Chediak-Higashi syndrome 
                Konrad Krzewski

     24       Ex-Vivo Expansion Induces Hyperfunctional CD56bright NK Cells with a Unique
                 Phenotype and Enhanced Cytotoxicity and Cytokine Production
                 Arianexys Aquino Lopez

     26       CD28 homolog (CD28H): a receptor on human NK cells that synergizes with
                other activation receptors       
                Xiaoxuan Zhuang  

     28       PD-L1-specific immunocytokines augment functionality and antitumor activity
                of CAR-engineered NK cells     
                Aline Lindner

    30       Inhibition of IL-10 secretion in CAR-engineered NK cells modulates polarization
                of bystander macrophages and enhances dendritic cell maturation         
               Anja Waldmann

    32       Comparison of phenotypic and functional characteristics between canine non-B,
               non-T NK lymphocytes and CD3+CD5dimCD21– cytotoxic large granular
               Sang-Ki Kim

    34       KIR3DS1/HLA-F interactions control Hepatitis C virus infection
               Sebastian Lunemann

    36       Natural killer cell-derived exosomes have tumor killing capability in vitro and in vivo,
               with the potential to be a natural immunotherapeutic agent 
               Allyson Cochran 

     38       Low CD160 Expression Contributes to NK Cell Exhaustion and Predicts a Poor
                Prognosis of Patients with Liver Cancer
                Cheng Sun

    40       Complete Remission with Reduction of High-risk Clones following Haploidentical
               NK Cell Therapy against MDS and AML          
               Andreas Bjorklund

    42       The Inhibitor of Apoptosis Protein (IAP), Birc5, is required for NK cell development
               Aimee M. Beaulieu

    44       ILC1 cells negatively regulate CD8+ T cells in PD-L1-dependent manner
               Jing Zhou

    46       Heterogeneity, development and functions of liver NK cell subsets
               Hui Peng

    48       FBP1 induces natural killer cell dysfunction by inhibiting glycolysis during lung
               cancer progression 
               Jingjing Cong             

    50       Strain-Specific Escape from Human Natural Killer Cells by Influenza A Virus
               Rosemary Vergara

    52       A2AR adenosine signaling suppresses natural killer cell maturation in the tumor
               Fernando SF Guimaraes

    54       CIS is a potent checkpoint in NK cell-mediated Immunity
               Rebecca Delconte

    56       A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population
               characterized by group 1 properties
               Georges Leclercq

    58       Anti CXCR4 antibody combined with activated and expanded natural killer cells
                infusions efficiently inhibits sarcoma metastasis
                Maria Vela

    60       Srebp-controlled glucose metabolism is essential for NK cell functional responses
               Katie O'Brien 

    62       MicroRNA-21 is a critical regulator of the anti-viral NK cell response
               Clair Geary

    64       HIV exposure and infection is associated with alterations natural killer cell phenotype
               Elena Vendrame          

    66       Harnessing NK Memory to Prevent Chronic HIV Infection
               Rana Nikzad

    68       CD38 drives exacerbated NK cell immune response to influenza virus during pregnancy
               Mathieu Le Gars             

    70       The Role of Hhex in Natural Killer Cell Development
                Wilford Goh

    72       TIGIT blockade prevents CTL and NK cell exhaustion and leads to tumor rejection in mice
               Hui Peng

    74       Mature Natural Killer cells possess essential anti-tumor functions in a novel mouse model of
               lung adenosquamous cancer
               Duy Le

    76       TNFAIP3/A20 as a critical regulator of NK cell biology
               Jessica Vetters

    78       Characterization of NK cell phenotype and function during obesity-induced liver inflammation
               in humans
               Natalie Stiglund

    80       Timing and localization of NK cell-mediated Granzyme B and Caspase-8 activity during serial
               killing of tumor cells
               Isabel Prager

    82       Donor intrinsic metabolic set points determine proliferation in human natural killer cells
               Aline Pfefferle

    84       Genome-wide analysis of Interleukin-21-induced STAT3 binding in ex vivo-expanded NK cells
               Nitin Chakravarti

    86       Uncovering mechanisms of synergy between cytokine and NK receptor signaling using mass
               cytometry and data driven in silico modeling
               Jayajit Das

    88       Stability of HLA-C*03:04/peptide - binding KIR2DL3+ Natural killer cells during viral
               Sebastian Lunemann

    90       Endometrial NK cells reveal a tissue-specific receptor repertoire
               Dorien Feyaerts

    92       CD16xCD33 and CD16xIL15xCD33 Bi- and Trispecific Killer Cell Engagers (BiKE/TriKE)
               as potential immunotherapy in Pediatric Patients with AML and Biphenotypic ALL
               Florian Babor

    94       Compelling adapted natural killer cells against malignancy
               Kayla Holder

    96       A novel NK cell-specific inducible Cre model reveals a critical role for Eomes in
               CD27+CD11b+ NK cell survival
               Julia Wagner

    98       Understanding the receptor-ligand interactions required for NK cell recognition
               of HIV
               Nancy Zhao

    100     Functional analysis of NK cell-cancer interaction in 3D microfluidic platform
               Dohyun Park

    102     Investigating mechanisms of Elotuzumab and Lenalidomide dual therapy in
               Multiple Myeloma
               Kelden Richardson

    104     Differences in the glycolytic profile of educated and uneducated NK cells
               Caroline Pfeifer

    106     Naïve NK cells in pediatric patients with acute leukemia
               Aina Ulvmoen

    108     NKG2Cpos NK cells associated with CMV infection inhibit expansion
               Christine Thöns

    110     NK cell detachment from target cells: killing as a social effect
               Ramit Mehr

    112     Contraction and expansion of KIR haplotypes
               Jesse Bruijnesteijn

    114     In vitro Expansion, Immune Synapse Formation and Cytotoxicity of Vy9Vd2 T-cells
               Patrick Sandoz

    116     Novel RNA Construct increases Perforin and Granzyme B in Natural Killer and Cytotoxic T cells
                Arnika Kathleen Wagner

    118     AHR: An Atypical Receptor Involved in NK cell development
                Prashant Trikha

    120     Interleukin-15 Primes Natural Killer Cell Functions through Proximal Crosstalk
               with Activating Receptors
               Petter Hoglund

    122     Platelets become NK cell targets in the presence of anti-platelet antibodies
               Petter Hoglund

    124     Type I Interferon-driven NK cell depletion – implications for viral infection and
               autoimmune disease
               Kelly Hudspeth

    126     Alloreactive natural killer cell therapy as novel approach for breast cancer
               Femke Ehlers

    128     Natural killer cells switch mechanism of cytotoxicity from Granzyme B to Caspase
               8-induced cytolysis during serial killing
               Hanna Van Ooijen

    130     Metabolic regulation of NK cell activation and memory formation
               Sam Sheppard

    132     PD-L1 blockade enhances NK cell efficacy against ovarian cancer
               Alicja Copik

    134     An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to
               NK Cell Maturation
               Erin Hillhouse

    136     A new malaria killer: Fc receptor gamma chain and PLZF identify NK cell subsets
               that correlate with reduced Plasmodium falciparum parasitemia and increased antibody
               dependent cellular cytotoxicity (ADCC) against opsonized infected RBCs
               Geoffrey Hart

    138     PD-L1 positive natural killer cells disrupt T cell function
               Rosa Sottile

    140     Variants of the immunodominant HCV NS5B2841 epitope presented by HLA B*27:05
                impact the function of KIR3DL1+ NK cells
               Tina Senff

    142     IL-15 treatment does not override human natural killer cell education and inhibition
               Zeguang Wu

    144     Cytomegalovirus infection drives avidity selection of natural killer cells
               Nicholas Adams

    146     Chronic TGFß stimulation of NK cells during activation by tumor targets leads to
               epigenetic and transcriptional reprogramming toward cytokine hypersecretion
               Jennifer Foltz

    148     microRNA-142 is critical for the homeostatic balance of type 1 innate lymphoid cells
               Melissa Berrien-Elliott

    150     NK clonal relationships in CMV positive and CMV negative rhesus macaques
               investigated by genetic barcoding
               Lauren Truitt

    152     Extracellular killing of Pseudomonas aeruginosa by Natural Killer cells
               David Feehan

    154     Investigating the role of NK cells in senescence surveillance in the liver
               Hsuan-An Chen

    156     Identification of the progenitor committed to liver-resident NK cells in murine liver
               Hui Peng

    158     Novel immunotherapy using liver natural killer cells for preventing recurrence of
               hepatocellular carcinoma in liver transplantation
               Masahiro Ohira

    160     Identification of human common ‘helper’ innate lymphoid cell precursors (CHILP)
               and the role of GATA3 for the development of the precursors
               Dejene Tufa

    162     NK-92 cells are cytotoxic to non-small cell lung cancers that have acquired resistance
               to tyrosine kinase inhibitors
               Yong-Oon Ahn

    164     Anti-HIV envelope (Env) specific antibodies (Abs) from HIV+ subject plasma support
                NK cell mediated Ab-dependent cellular cytotoxicity (ADCC) to target cells expressing
                closed conformation HIV Env
                Nicole Bernard

    166     Regulation of ILC1 and NK cell plasticity by TGF-b signaling pathways
                Victor Cortez

    168     Genome-wide analyses and functional profiling of human NK cell lines
                Justin Tyme Gunesch

    170     Deregulated actin processes in CD56-deficient human NK cells
                Amera Dixon

    172     Natural Killer Cells Targeting the Suppressive Immune Microenvironment Rescue
                Car-T Cell Activity within Solid Tumors
                Robin Parihar

    174     Local Proliferation of Uterine Tissue-Resident NK Cells During Early Pregnancy
                Dorothy Sojka                                                                                                              

    176     Tissue-specific neuroendocrine regulation of NCR1+ innate lymphoid cell functions is
                required for host antiviral defence
                Sophie Ugolini

    178     NK-cell alloreactivity is associated with acute GVHD and decreased relapse incidence
               after T-replete haplo-identical allotransplant with high-dose post-transplant cyclophosphamide
               Christelle Retiere

    180     NK cells are essential for brain inflammation but their maturation is severely
               compromised in infected newborn mice
               Ilija Brizic

    182     MCMV expressing high affinity NKG2D ligand MULT-1: a model vaccine for congenital
               CMV infection
               Lea Hiršl

    184     CD127+ Innate Lymphoid Cells (ILCs) with NK cell features accumulate in
               Inflammatory Bowel Disease (IBD)
               Lisette Krabbendam

    186     Tuning of NK-Specific HLA-C Expression by alternative mRNA splicing
               Stephen Anderson

    188     Targeting residual chronic myeloid leukemia with NK cell-stimulatory immunotherapy
                Elin Bernson

    190     Absence of STAT5b causes dysregulated human natural killer cell maturation in both
               humans and mice
               Alexander Vargas-Hernandez

    192     NKG2A Expression is Not per se Detrimental for the Anti-Multiple Myeloma Activity
                of High Dose IL-2 Activated Natural Killer Cells in an In Vitro System Mimicking the
                Tumor Microenvironment
                Lotte Wieten

    194     Natural killer cells in the synovial fluid of children with juvenile idiopathic arthritis
                potentially contribute to autoimmune dysregulation
                Florian Babor

    196     Tumor microenvironment regulates metabolism of Natural Killer cells and modulates
                the expression of immunomodulatory receptors
                Venkateswara Simhadri

    198     Impact of the HLA-B -21 dimorphism on outcome of AML immunotherapy
               Alexander Hallner

    200     Identification of Molecular Markers for Tumor Cell Responses to Natural Killer Cells
               Through CRISPR-Based Screens and Large-Scale Phenotypic Screens of Pooled
               Tumor Cell Lines
               Michal Sheffer

    202     High frequencies of CXCR6+ NK cells in bone marrow of pediatric acute leukemia
               patients correlate with increased risk of treatment failure
               Marit Inngjerdingen

    204     IL-15 stimulated NK cells can clear HIV infected cells following latency reversal
               Carolina Garrido

    206     NKG2A as a therapeutic target to improve NK cells alloreactivity to cure
                haploidentical hematopoietic stem cell transplanted patients
                Elisa Zaghi

    208     The Impact of KLRC2 gene deletions on Natural Killer cell function in Gambian adults
                Martin Goodier 

    210     Use of an ADAM17 mAb to enhance human NK cell activation by CD16A and their
                release of IFN? 
                Bruce Walcheck

    212     AFM13 – A first-in-class tetravalent bispecific NK-cell engager to treat
                CD30-positive lymphomas
                Martin Treder

    214     Human PLCG2 Haploinsufficiency Results in Natural Killer Cell Immunodeficiency
               and Herpesvirus Susceptibility
               Joshua Alinger


Thursday, May 31, 2018

6:00 – 3:00 pm                  Registration Open  

6:30 – 8:30 am                  Breakfast  

8:30 – 10:00 am                NK Cell Development and Differentiation
                                            Chair:    Aharon Freud

8:30 – 8:50 am                  Christian Vosshenrich

8:50 – 9:10 am                  Barbara Kee

9:10 – 9:30 am                  Emily Mace

9:30 – 9:50 am                  Michael Caliguiri

9:50 – 10:00 am     10       TRPML1-mediated Modulation of Dense-core Granules Determines
                                            Functional Potential in NK Cells
                                            Jodie Goodridge

10:00 – 10:30 am              Coffee Break

10:00 – 1:00 pm                Exhibition Hall open  

10:30 – 12:00 pm             NK Cell Memory
                                           Chair:    Laurent Brossay

10:30 – 10:50 am             Joseph Sun

10:50 – 11:10 am             Silke Paust

11:10 – 11:30 am             R. Keith Reeves

11:30 – 11:40 am   11      Human liver- and skin-derived NK cells exhibit antigen-specific memory responses
                                           Georg Stary

11:40 – 11:50 am   12      MHC I-specific MCMV control requires NK cells co-expressing inhibitory Ly49G2
                                            and stimulatory Ly49R receptors
                                            Awndre Gamache

11:50 – 12:00 pm   13      Tissue-resident NK cells in human lung
                                            Nicole Marquardt

12:00 – 1:30 pm                Lunch & Networking

1:30 – 3:00 pm                  NK Cell Immunotherapy and Immunomodulation*
                                            Chair:    Michael Verneris

1:30 – 1:50 pm                  Jeffrey Miller

1:50 – 2:10 pm                  Todd Fehniger

2:10 – 2:30 pm                  Dean Lee

2:30 – 2:40 pm       14       IL-1R8: a novel checkpoint regulating anti-tumor and anti-viral activity of NK cells
                                             Martina Molgora

2:40 – 2:50 pm       15       Unsupervised High-Dimensional Analysis Unravels NK Cell Diversity Across
                                             Tissues and Species
                                             Adeline Crinier

2:50 – 3:00 pm       16       Preclinical characterization of an off-the-shelf chimeric antigen
                                             receptor-engineered NK cell therapeutic for adoptive cancer immunotherapy
                                             Congcong Zhang

3:00 – 6:00pm                   Free Time           

6:00 – 10:30 pm                Gala Dinner 
                                            Mike Bennet Abstract Awardee Presentation


Friday, June 1, 2018

6:00 – 12:00 pm                Registration Open

6:30 – 8:30 am                  Breakfast  

8:30 – 10:00 am                Tissue-Associated NK Cell Subsets and NK Cells in Pregnancy
                                            Chair:    Sophie Ugolini

8:30 – 8:50 am                  Francesco Colucci

8:50 – 9:10 am                  TBA

9:10 – 9:30 am                  Wayne Yokoyama

9:30 – 9:40 am       17       NKp46/NCR1 controls TRAIL protein expression in NK cells and ILC1
                                            Nadia Guerra

9:40 – 9:50 am       18       Transcription factor control of type 1 innate lymphoid cells
                                            Stephen Waggoner

9:50 – 10:00 am     19       Abundance of mucosal NK cells in the small intestine of young infants
                                            Adrian Sagebiel

10:00 – 10:30 am             Coffee Break  

10:30 – 12:00 pm             NK Cell Receptors and Education
                                           Chair:    Kerry Campbell

10:30 – 10:50 am             Andre Veillette

10:50 – 11:10 am             Eric Vivier

11:10 – 11:30 am             Karl-Johan Malmberg

11:30 – 11:50 am             Catherine Blish

11:50 – 12:00 pm   20     KIR2DS4 binds HLA-C*05:01 carrying rare ‘self’ peptides and peptides
                                           derived from a protein highly conserved in pathogenic bacteria
                                           Malcolm Sim


*CME Offered for Session